Paclitaxel 33069-62-4 Umuti urwanya ibibyimba Ubuvuzi bwa Botaniki ya Kanseri yintanga, Kanseri y'ibere
Ibicuruzwa birambuye
| Izina | Yamazaki |
| Numero ya CAS | 33069-62-4 |
| Inzira ya molekulari | C47H51NO14 |
| Uburemere bwa molekile | 853.92 |
| Umubare wa EINECS | 608-826-9 |
| Ingingo | 774.66 ° C (Biteganijwe) |
| Ubucucike | 0.200 |
| Imiterere y'ububiko | Ikidodo cyumye, Ubike muri firigo, 2-8 ° C. |
| Ifishi | Ifu |
| Ibara | Cyera |
| Gupakira | Umufuka wa PE + Aluminium |
Synonyme
Paclitaxel HCL; Paclitaxel;
Ingaruka ya Farumasi
Ibisobanuro
Paclitaxel ni monomeric diterpenoid yakuwe mu kibabi cy’ibimera bisanzwe imiti ya Taxus.Gukurikirana Isotope byerekanaga ko paclitaxel ihambiriye gusa microtubules ya polymerized kandi ntigire icyo ikora hamwe na dimuline ya tubuline idafite polimerize.Ingirabuzimafatizo zimaze guhura na paclitaxel, umubare munini wa microtubules uzegeranya muri selile.Ikusanyirizo rya microtubules ribangamira imirimo itandukanye ya selile, cyane cyane igabana rya selile rihagarara mugice cya mitoto kandi rikabuza kugabana bisanzwe kwingirabuzimafatizo.Binyuze mu bushakashatsi bw’ubuvuzi, paclitaxel ikwiriye cyane cyane kanseri yintanga na kanseri yamabere, kandi ikagira n'ingaruka zimwe na zimwe zo kuvura kanseri y'ibihaha, kanseri yibara, melanoma, kanseri yo mu mutwe no mu ijosi, lymphoma n'ikibyimba mu bwonko.
Ibyerekana
Ifite ingaruka nziza mukuvura kanseri yintanga na platine nizindi kanseri yintanga ngore na kanseri yamabere.Kanseri, kanseri yo mu gifu yo hejuru, selile nto na kanseri y'ibihaha itari ntoya bifite icyerekezo cyiza.
Imikoreshereze
Koresha 1: Umuyoboro mugari urwanya ibibyimba bya kanseri yintanga, kanseri yamabere, nibindi.
Koresha 2: imiti myinshi igabanya ubukana bwa botaniki yo kuvura kanseri yintanga, kanseri yamabere nizindi ndwara.
Koresha 3: Imiti igabanya ubukana.Kuvura kanseri y'ibere metastatike na kanseri yintanga.Ikwirakwizwa ryinshi rya anti-tumor botanicals yo kuvura kanseri yintanga, kanseri yamabere nizindi ndwara.
Koresha 4: Umuti urwanya ibibyimba neza;Ihuza akarere ka N-terminal ya tub-tubuline, iteza imbere microtubule ikora cyane, irwanya depolymerisation, irinda igabana risanzwe ryimitego hamwe numutego mugice cya G2 / M cyinzira ya selile.
Koresha 5: Umuti urwanya microtubule, uhagarika depolymerisation uteza imbere polimerisiyasi ya tubuline, kubungabunga tubuline, no kubuza mitito.
