Daptomycine 103060-53-3 ku ndwara zandura
Ibicuruzwa birambuye
| Izina | Daptomycin |
| Numero ya CAS | 103060-53-3 |
| Inzira ya molekulari | C72H101N17O26 |
| Uburemere bwa molekile | 1620.67 |
| Umubare wa EINECS | 600-389-2 |
| Ingingo yo gushonga | 202-204 ° C. |
| Ingingo yo guteka | 2078.2 ± 65.0 ° C (Biteganijwe) |
| Ubucucike | 1.45 ± 0.1 g / cm3 (Biteganijwe) |
| Ingingo ya Flash | 87 ℃ |
| Imiterere yo kubika | Ikidodo cyumye, Ubike muri firigo, munsi ya -20 ° C. |
| Gukemura | Methanol: gushonga5mg / mL |
| Coefficient ya acide | (pKa) 4.00 ± 0.10 (Biteganijwe) |
| Ifishi | ifu |
| Ibara | ibara ritagira ibara ry'umuhondo |
Synonyme
N- [N- (1-Oxodecyl) -L-Trp-D-Asn-L-Asp -] - cycl [L-Thr * ; N- [N-Decanoyl-L-Trp-D-Asn-L-Asp -] - cyclo [Thr * -Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser - ecyl) -L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl- (3R) -3-methyl-L-α- glutamyl-α, 2-diamino-γ-oxo-benzenebutanoicacid (13-4) lactone; DAPTOMYCINE; Dapcin; Daptomycin,> = 99%; DaptomycinReadyMadeSolution; Daptomycin (LY146032)
Ibisobanuro
Antibiyotike ya daptomycine ni antibiyotike ya cyclicale lipopeptide ifite imiterere mishya yakuwe mu musemburo wa fermentation ya Streptomyces (S. reseosporus), ikabuza biosynthesis y'urukuta rwa bagiteri peptidoglycan guhungabanya ubwikorezi bwa aside amine muri selile. Guhindura imiterere ya cytoplasmeque membrane irashobora guhagarika imikorere ya bagiteri mumikorere myinshi kandi ikica byihuse bacteri nziza. Usibye ubushobozi bwayo bwo gukora kuri bagiteri nyinshi zifata Gram-positif, daptomycine ningirakamaro cyane kumiterere yihariye yerekanye kurwanya methicilline, vancomycine, na linezolide muri vitro. Ifite ibikorwa bikomeye, kandi uyu mutungo ufite akamaro gakomeye mubuvuzi kubarwayi banduye cyane. Umusonga wa Eosinophilique ni indwara idasanzwe kandi ikomeye cyane ifite ibimenyetso birimo umuriro, inkorora, guhumeka neza, no guhumeka neza.
Ingaruka ya Antibacterial
Daptomycine ifite ibikorwa byiza bya bacteriostatike irwanya bagiteri zitandukanye zirwanya antibiyotike, nka MIC = 0.06-0.5 μg / ml kuri methicilline irwanya Staphylococcus aureus (MRSA), hamwe na methacilline irwanya Staphylococcus aureus (MRSA). MIC = 0.0625. antibiyotike ya glycopeptide ni 1 ～ 2μg / ml.
