Leuprorelin Acetate igenga ibanga rya hormone ya Gonada
Ibisobanuro birambuye
| Izina | Leprorelin |
| Umubare wa Cas | 53714-56-0 |
| Formulala | C59H84N16O12 |
| Uburemere bwa molekile | 1209.4 |
| Umubare wa EINECS | 633-395-9 |
| Kuzunguruka | D25 -31.7 ° (C = 1 muri 1% acide acide) |
| Ubucucike | 1.44 ± 0.1 g / cm3 (byahanuwe) |
| Imiterere | -15 ° C. |
| Ifishi | Neat |
| Coeffity | (PKA) 9.82 ± 0.15 (byahanuwe) |
| Amazi | Gushonga mumazi kuri 1mg / ml |
Synonyme
LH-RHLLEUPLANDE; Leuplide; Leuprol (Umuntu); Leuprorelin; -Nhet9) -Luriinisehormone-Kurekura; (des-gly10, D-leu6, Pros-Gly
Ingaruka ya farumasi
Leuprolide, Goserelin, na Nafarelin, ni ibiyobyabwenge byinshi bikunze gukoreshwa mumyitozo ngororamubiri kugira ngo ukureho intanga ngorerere intanga ngorerere premenopausa na kanseri ya prostate. . Ni ukuvuga, Gonadopropin isohoka na mitoire igabanuka, biganisha ku kugabanuka kwinshi mu misemburo yimibonano mpuzabitsina ihinduka na ovary.
Leuprolide ni Gonmone ya Gonadopropin-kurekura (GNRH) Analog, Peptade igizwe na 9 amino. Iki gicuruzwa kirashobora kubuza neza imikorere ya sisitemu ya Pitoitary-Gonaday, irwanya imisatsi ya Protomeriya hamwe na GNRH Reseptor irusha GNRH, nigikorwa cyo guteza imbere irekurwa rya luteine (lh) rifite inshuro 20 za GNR. Ifite kandi ingaruka zikomeye zibangamira imikorere ya pituitary-gonad kuruta gnrh. Mu cyiciro cyambere cyo kuvura, Folticle gitera imisemburo (Fsh), LH, Estrogene cyangwa na Anderogen irashobora kwiyongera kw'igihe gito, kandi, kubera ko yagabanijwe by'agateganyo, hanyuma, kandi estrogene cyangwa na estrogen cyangwa na Estrogen cyangwa na Estrogen cyangwa bo muri Estrogen cyangwa bongere babuza kwishingikiriza kuri hormone igitsina. Indwara zimibonano mpuzabitsina (nka kanseri ya prostate, endometriose, nibindi) zifite ingaruka zumuco.
Kugeza ubu, umunyu wa acetate wo kwibeshye ukoreshwa cyane cyane ubuvuzi, kuko imikorere ya acetate ihamye ikaze ku bushyuhe bwicyumba. Amazi agomba gutabwa. Irashobora gukoreshwa mugutunganya ibiyobyabwenge bya endometriose na febroide ya nyababyeyi, kanseri yibanze yibanze, kanseri ya premonausal na kanseri ya prostate, ndetse no kuvanga inganda zikora neza cyangwa bidahwitse kumivugo isanzwe. Irashobora kandi gukoreshwa nkigituba mbere yo gutangwa endometrial, ishobora kuba inanutse endometrium, kugabanya edema, no kugabanya ingorane zo kubaga.
