Leuprorelin Acetate igenga ibanga rya hormone ya Gonadal
Ibicuruzwa birambuye
| Izina | Leuprorelin |
| Numero ya CAS | 53714-56-0 |
| Inzira ya molekulari | C59H84N16O12 |
| Uburemere bwa molekile | 1209.4 |
| Umubare wa EINECS | 633-395-9 |
| Kuzenguruka byihariye | D25 -31.7 ° (c = 1 muri 1% acide acike) |
| Ubucucike | 1.44 ± 0.1 g / cm3 (Biteganijwe) |
| Imiterere y'ububiko | -15 ° C. |
| Ifishi | Isuku |
| Coefficient ya acide | (pKa) 9.82 ± 0.15 (Biteganijwe) |
| Amazi meza | Gushonga mumazi kuri 1mg / ml |
Synonyme
LH-RHLEUPROLIDE; LEUPROLIDE; LEUPROLIDE (UMUNTU); LEUPRORELIN; [DES-GLY10, D-LEU6, PRO-NHET9] -NHET9) -LUTEINIZINGHORMONE-RELEASINGHORMONE; (DES-GLY10, D-LEU6, PRO-NHET9)
Ingaruka ya Farumasi
Leuprolide, goserelin, triprelin, na nafarelin ni imiti myinshi ikunze gukoreshwa mu buvuzi kugira ngo ikure intanga ngore zo kuvura kanseri y'ibere mbere yo gucura na kanseri ya prostate. . Ni ukuvuga, gonadotropine isohorwa na pitoito iragabanuka, bigatuma igabanuka rikabije ryimisemburo yimibonano mpuzabitsina isohoka nintanga ngore.
Leuprolide ni imisemburo ya gonadotropine irekura (GnRH), peptide igizwe na acide 9 amine. Iki gicuruzwa kirashobora guhagarika neza imikorere ya sisitemu ya pituito-gonadal, kurwanya imisemburo ya proteolyique no kuba hafi ya reseptor ya GnRH yakira kurusha GnRH, kandi igikorwa cyo guteza imbere irekurwa rya hormone ya luteinizing (LH) nikubye inshuro 20 GnRH. Ifite kandi ingaruka zikomeye zo kubuza imikorere ya pituito-gonad kuruta GnRH. Mu cyiciro cya mbere cyo kuvura, imisemburo itera imisemburo (FSH), LH, estrogene cyangwa androgene irashobora kwiyongera by'agateganyo, hanyuma, kubera kugabanuka kwa glande ya pitoito, gusohora kwa FSH, LH na estrogene cyangwa androgene birabujijwe, bikaviramo gushingira ku misemburo y’imibonano mpuzabitsina. Indwara zishingiye ku gitsina (nka kanseri ya prostate, endometriose, nibindi) zigira ingaruka zo kuvura.
Kugeza ubu, umunyu wa acetate wa leuprolide ukoreshwa cyane cyane mubuvuzi, kubera ko imikorere ya acupate ya leuprolide ihagaze neza mubushyuhe bwicyumba. Amazi agomba gutabwa. Irashobora gukoreshwa mu kuvura imiti ivura endometriose na fibroide yo muri nyababyeyi, ubwangavu bwibanze, kanseri y'ibere mbere yo gucura na kanseri ya prostate, ndetse no kuva amaraso munda ibyara yanduye cyangwa adafite akamaro ko kuvura imisemburo isanzwe. Irashobora kandi gukoreshwa nkubushake mbere yo kwanga endometrale, ishobora kunanura endometrium, kugabanya indurwe, no kugabanya ingorane zo kubagwa.
