Liraglutide Irwanya Diyabete yo Kugenzura Isukari Yamaraso CAS NO.204656-20-2
Ibicuruzwa birambuye
| URUBANZA | 204656-20-2 | Inzira ya molekulari | C172H265N43O51 |
| Uburemere bwa molekile | 3751.20 | Kugaragara | Cyera |
| Imiterere y'Ububiko | Kurwanya urumuri, dogere 2-8 | Amapaki | Umufuka wa aluminium / vial |
| Isuku | ≥98% | Ubwikorezi | Urunigi rukonje no gutanga ububiko bukonje |
Ibigize Liraglutide
Ibikoresho bifatika:
Liraglutide (igereranya na glucagon ya muntu isa na peptide-1 (GLP-1) ikorwa n'umusemburo binyuze mu ikoranabuhanga rya genoside).
Izina ryimiti:
Arg34Lys26- (N-ε- (γ-Glu (N-α-hexadecanoyl))) - GLP-1 [7-37]
Ibindi bikoresho:
Disodium Hydrogen Fosifate Dihydrate, Propylene Glycol, Acide Hydrochloric na / cyangwa Sodium Hydroxide (nka pH Adjusters gusa), Fenol, namazi yo gutera inshinge.
Gusaba
Ubwoko bwa diyabete yo mu bwoko bwa 2
Liraglutide itunganya neza glucose yamaraso. Igabanya hyperglycemia ifitanye isano nifunguro (mumasaha 24 nyuma yubuyobozi) mukongera insuline ya insuline (gusa) mugihe bisabwa mukongera glucose, gutinda gusohora gastrica, no guhagarika ururenda rwa glucagon.
Irakwiriye abarwayi bafite isukari yamaraso ikomeje kugenzurwa nabi nyuma yumuti wihanganirwa wa metformine cyangwa sulfonylure yonyine. Ikoreshwa ifatanije na metformin cyangwa sulfonylureas.
Ikora muburyo bushingiye kuri glucose, bivuze ko izatera insuline gusohora gusa mugihe glucose yamaraso irenze iyisanzwe, ikarinda "kurenza urugero". Kubera iyo mpamvu, yerekana ingaruka zitari nke za hypoglycemia.
Ifite ubushobozi bwo guhagarika apoptose no gutera imbaraga kuvugurura ingirabuzimafatizo (bigaragara mu bushakashatsi bw’inyamaswa).
Igabanya ubushake bwo kurya no kubuza kwiyongera k'umubiri, nkuko bigaragara mu bushakashatsi bwakozwe ku mutwe na glimepiride.
Igikorwa cya farumasi
Liraglutide nikigereranyo cya GLP-1 hamwe na 97% bikurikirana homologiya kubantu GLP-1, ishobora guhuza no gukora reseptor ya GLP-1. Umuyoboro wa GLP-1 niwo wibasiwe na GLP-1 kavukire, imisemburo ya endogenous incretin itera imisemburo ya glucose iterwa na insuline ituruka mu ngirabuzimafatizo. Bitandukanye na GLP-1 kavukire, imiterere ya pharmacokinetic na pharmacodynamic ya liraglutide mubantu ikwiranye nuburyo bwo gufata inshuro imwe kumunsi. Nyuma yo guterwa inshinge, uburyo bwibikorwa byigihe kirekire birimo: kwishyira hamwe bidindiza kwinjiza; guhuza albumin; Enzyme yo hejuru ihamye bityo plasma ndende yubuzima.
Igikorwa cya liraglutide gihuza imikoranire yihariye na reseptor ya GLP-1, bigatuma kwiyongera kwa cyclic adenosine monophosphate (cAMP). Liraglutide itera gusohora kwa insuline muburyo bushingiye kuri glucose, mugihe igabanya glucagon irenze urugero muburyo bwa glucose.
Kubwibyo, iyo glucose yamaraso izamutse, insuline isohoka, mugihe glucagon isohoka. Ibinyuranye, liraglutide igabanya imisemburo ya insuline mugihe cya hypoglycemia itagize ingaruka kuri glucagon. Uburyo bwa hypoglycemic ya liraglutide burimo no kwongerera gato igihe cyo gusiba gastric. Liraglutide igabanya uburemere bwumubiri hamwe n’ibinure byumubiri bigabanya inzara ningufu.
