Liraglutide Anti-diabete kumaso y'isukari yamaraso
Ibisobanuro birambuye
| Cas | 204656-20-20-20-2 | Formulala | C172H265N43O51 |
| Uburemere bwa molekile | 3751.20 | Isura | Cyera |
| Imiterere | Kurwanya urumuri, Impamyabumenyi 2-8 | Paki | Aluminium foil bag / vial |
| Ubuziranenge | ≥98% | Ubwikorezi | Urunigi rukonje nububiko bukonje |
Ibikoresho bya liraglutide
IGIKORWA CY'INGENZI:
Liraglutide (Analog of Dan Glucagon-nka Peptide-1 (GLP-1) yakozwe numusemburo binyuze mu ikoranabumenyi rya genetike).
Izina ry'Umutima:
Arg34lys26- (n-γ-glu (n-α-hexcanoyl))) - GLP-1 [7-37]
Ibindi bikoresho:
Dishrogen fosphate diphyrate, propylene glycol, aside hydrochloric na / cyangwa sodium hydroxide (nkuko ph ishishikarizwa gusa), fenol, namazi yo gutera inshinge.
Gusaba
Ubwoko bwa diyabete 2
Liraglutide itezimbere igenzura macocose yamaraso. Igabanya ifunguro rya Hyperglycemia bijyanye (kumasaha 24 nyuma yubuyobozi) mu kongera imbaraga za insuline (gusa) mugihe bisabwa mukwiyongera mu nzego za glucose, kandi zikagira imbaraga za glucagont.
Birakwiriye abarwayi isukari yamaraso iracyayoborwa nabi nyuma yikigereranyo ntarengwa cyo kwishyurwa kwa metformin cyangwa Sulmoorelureas wenyine. Ikoreshwa mu guhuza na Metformin cyangwa Sulmoonas.
Ikora muburyo bushingiye kuri glucose, bivuze ko izamura insuline insumin gusa mugihe urwego rwamaraso ruruta ibisanzwe, kwirinda "evershoot". Kubera iyo mpamvu, byerekana ibyago bike bya hypoglycemia.
Ifite ubushobozi bwo kubuza acoptose no gukangurira kuvugurura selile (bigaragara mubushakashatsi bwinyamaswa).
Bigabanya ubushake bwo kurya no kubuza inyungu zumubiri, nkuko bigaragara mubyigisho-kumutwe bitandukanye.
Ibikorwa bya farumasi
Liraglutide ni GLP-1 Ikigereranyo hamwe 97% Urukurikirane rwa GLP kuri Glp-1, ishobora guhambira no gukora reseptor ya GLP-1. GLP-1 Kwakira nintego ya kavukire-1, endogenous increatin iteza imbere kwa glucose kwibanda kuri selire ya pancreatic iva muri parickati. Bitandukanye na Glp-1, imyirondoro ya farumacoditique na farumawodic ya liraglutide mubantu irakwiriye guterana burundu. Nyuma yo gutera inshinge, uburyo bwacyo bwibikorwa birurutse arimo: kwishyira hamwe bitinda kwikuramo; bihuza albumu; Guhagarara Byuzuye Byumutekano bityo birebire Plasma igice cya kabiri.
Igikorwa cya Liraglutide gisukuwe nuburyo bwihariye na reseptor ya GLP-1, bikaviramo kwiyongera muri monohosphate yamenesi (inkambi). Liraglutide itera imbaraga za insuline muburyo bwa glucose imyumvire ishingiye kuri glucose, mugihe bigabanya urusaku rurenze rwa Glucagon muri Glucagon muri Glucose Clucase
Kubwibyo, mugihe amaraso glucose yazamutse, ubusekuru bwa insuline bushimwe, mugihe isi ya glucagon ibuzwa. Ibinyuranye, Liraglutide igabanya ubusemburo bwa insuline mugihe hypoglycemia nta byangejwe ku mbuga ya glucagon. Uburyo bwa hypoglycemic ya Liraglutide nayo ikubiyemo igihe gito cyo kurasa. Liraglutide igabanya uburemere bwumubiri numubiri wumubiri mu kugabanya inzara n'ingufu.
