Paclitaxel 33069-64-4--4-4 Ubuvuzi bwibibyimba kuri kanseri ya ovarian
Ibisobanuro birambuye
| Izina | Paclitaxel |
| Umubare wa Cas | 33069-62-4 |
| Formulala | C47h51no14 |
| Uburemere bwa molekile | 853.92 |
| Umubare wa EINECS | 608-826-9 |
| Ingingo itetse | 774.66 ° C (byahanuwe) |
| Ubucucike | 0.200 |
| Imiterere | Gufunga byuzuye, ububiko muri firigo, 2-8 ° C. |
| Ifishi | Ifu |
| Ibara | Cyera |
| Gupakira | Pe Umufuka + Umufuka wa Aluminium |
Synonyme
Paclitaxel HCL; Paclitaxel (Crude Kamere); Pheltaxelx; N-Betazyl-beta-perlilusie;
Ingaruka ya farumasi
Ibisobanuro
Paclitaxel ni DiTerPeNoot yakuwe mubishishwa byumutima wibihingwa bisanzwe. Gukurikirana isotope byerekanaga ko Paclitaxel yahambiye microtubele nyinshi kandi ntiyigeze yitwara na tululin yemereye tutulin. Nyuma yuko selile zihuye na paclitaxel, umubare munini wa microturules uzakusanyirizwa hamwe muri selile. Kwegeranya ibi bihingwa bibangamira imirimo itandukanye ya selile, cyane cyane kugabana selile bihagarara muri icyiciro cya Mitotic kandi bihagarika amacakubiri asanzwe ya selile. Binyuze kuri ⅱ-ⅲ Ubushakashatsi bwa Clinical, Paclitaxel ahanini akwiriye cyane kuri kanseri ya ovarian na kanseri y'ibere, kandi ifite ingaruka zimwe na kanseri y'ibihaha, muri kanseri y'amaraso, Melanoma, muri Melanoma, Umujyi n'igifuni cy'ubwonko.
Ibimenyetso
Ifite ingaruka nziza mu kuvura kanseri ya ovarian na platine hamwe na kanseri ya ovarian na kanseri y'ibere. Kanseri, kanseri yo hejuru ya gastrointestinal, selile nto hamwe na kanseri idafite kare kare ibihaha ibihaha bifite imyumvire myiza.
Imikoreshereze
Koresha 1: Umugari-wa Spectrum Anti-ibibyimba byo muri kanseri ya ovarian, kanseri y'ibere, nibindi.
Koresha 2: Umugari-wa Spectrum Anti-ibibyimba byo kuvura kanseri ya ovarian, kanseri y'ibere n'izindi ndwara.
Koresha 3: ibiyobyabwenge bya antituor. Ku rwego rwo kuvura kanseri y'ibere ya Metastatike na kanseri ya ovasike. Igituba kinini-spectrum kirwanya ibibyimba byo kuvura kanseri ya ovarian, kanseri y'ibere n'izindi ndwara.
Koresha 4: ibiyobyabwenge byiza byo kurwanya ibibyimba; Ihuze mukarere ka n-terminal ya β-tubulin, biteza imbere imiyoboro ihamye cyane, irwanya depoléiriryation, irinda imitego isanzwe ya selile hamwe nimitego muri G2 / M yicyiciro cyakagari.
Koresha 5: Ibiyobyabwenge byo kurwanya microtubule, kubuza depolénariation mugutezimbere tubulin polymeiring, kubungabunga igituba cya tubulin, kandi kibuza selire.
