Ibicuruzwa

Peptide Yera Yinshi Retatrutide 10mg yo Kugabanya Ibiro na Diyabete

Isuku:> 99%

Leta: Ifu ya Lyofilize

Kugaragara: Ifu yera

Ibisobanuro: 5mg / 10mg / 15mg / 20mg / 30mg

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Retatrutide

Retaglutide ni dipeptidyl peptidase-4 (DPP-4) inhibitor yo mu bwoko bwa hypoglycemic imiti ishobora kwirinda iyangirika rya glucagon imeze nka peptide-1 (GLP-1) hamwe na glucose iterwa na insuline irekura polypeptide (GIP) ikoresheje insimburangingo ya insuline mu gihe cyo kwanduza insuline. gusohora glucagon na pancreatic α selile, bityo bikagenzura neza isukari yamaraso nyuma yinyuma. Ikora neza mubijyanye n'ingaruka za hypoglycemic, kwihanganira, no kubahiriza.

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Inclisiran sodium

Inclisiran sodium API (Active Pharmaceutical Ingredient) yizwe cyane cyane mubijyanye no kwivanga kwa RNA (RNAi) hamwe nubuvuzi bwumutima. Nka siRNA ikubye kabiri yibasira gene PCSK9, ikoreshwa mubushakashatsi bwibanze nubuvuzi kugirango isuzume ingamba zimaze igihe zicecekesha gene yo kugabanya LDL-C (cholesterol ya lipoprotein nkeya). Ikora kandi nk'icyitegererezo cyo gukora iperereza kuri sisitemu yo gutanga siRNA, ituze, hamwe na RNA ivura umwijima.

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Fmoc-Gly-Gly-OH

Fmoc-Gly-Gly-OH ni dipeptide ikoreshwa nkigice cyibanze cyubaka muri synthesis ya peptide ikomeye (SPPS). Igaragaza ibisigazwa bibiri bya glycine hamwe na N-terminus irinzwe na Fmoc, ituma urunigi rwa peptide rugenzurwa. Bitewe na glycine ntoya kandi yoroheje, iyi dipeptide ikunze kwigwa murwego rwimikorere ya peptide yingirangingo, igishushanyo mbonera, hamwe no kwerekana imiterere muri peptide na proteyine.

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Fmoc-Thr (tBu) -Phe-OH

Fmoc-Thr (tBu) -Phe-OH ni inyubako ya dipeptide ikunze gukoreshwa muburyo bukomeye bwa peptide ya peptide (SPPS). Itsinda rya Fmoc (9-fluorenylmethyloxycarbonyl) ririnda N-terminus, mugihe itsinda rya tBu (tert-butyl) ririnda hydroxyl kumurongo wa threonine. Iyi dipeptide ikingiwe yizwe kubera uruhare rwayo mu korohereza peptide neza, kugabanya ivanguramoko, no kwerekana imiterere yihariye ikurikirana mu miterere ya poroteyine no mu bushakashatsi bwakozwe.

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AEEA-AEEA

AEEA-AEEA ni hydrophilique, icyogajuru cyoroshye gikoreshwa mubushakashatsi bwa peptide nubushakashatsi bwibiyobyabwenge. Igizwe nibice bibiri bishingiye kuri Ethylene glycol, bituma iba ingirakamaro mukwiga ingaruka zuburebure bwihuza no guhinduka kumikoranire ya molekile, solubile, nibikorwa byibinyabuzima. Abashakashatsi bakunze gukoresha ibice bya AEEA kugirango basuzume uburyo icyogajuru kigira ingaruka kumikorere ya antibody-ibiyobyabwenge (ADCs), peptide-ibiyobyabwenge, nibindi bioconjugate.

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Fmoc-L-Lys [Eic (OtBu) -γ-Glu (OtBu) -AEEA] -OH

Uru ruganda nirinda lysine rukoreshwa, rukoreshwa muri synthesis ya peptide no guteza imbere ibiyobyabwenge. Irimo itsinda rya Fmoc kurinda N-terminal, hamwe no guhindura urunigi kuruhande hamwe na Eic (OtBu) (inkomoko ya acide eicosanoic), acid-glutamic aside (γ-Glu), na AEEA (aminoethoxyethoxyacetate). Ibi bice byateguwe kugirango bige ku ngaruka za lipidation, chimie spacer, no kugenzura ibiyobyabwenge. Irakorwaho ubushakashatsi cyane murwego rwingamba za prodrug, guhuza ADC, na peptide ikorana na membrane.

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Fmoc-L-Lys [Ste (OtBu) -γ-Glu- (OtBu) -AEEA-AEEA] -OH

Uru ruganda ni lysine yahinduwe ikoreshwa muri synthesis ya peptide, cyane cyane mukubaka peptide ya conjugate cyangwa intego nyinshi. Itsinda rya Fmoc ryemerera guhuza intambwe ikoresheje Fmoc ikomeye-icyiciro cya peptide synthesis (SPPS). Urunigi rwo ku mpande rwahinduwe hamwe na aside ikomoka kuri stearic (Ste), acid-glutamic aside (γ-Glu), hamwe na AEEA (aminoethoxyethoxyacetate) ebyiri, zitanga hydrophobicity, ibintu byishyuza, hamwe n’imyanya yoroheje. Ubusanzwe yizwe kubera uruhare rwayo muri sisitemu yo gutanga ibiyobyabwenge, harimo antibody-ibiyobyabwenge conjugate (ADCs) na peptide yinjira mu ngirabuzimafatizo.

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Liraglutide Irwanya Diyabete yo Kugenzura Isukari Yamaraso CAS NO.204656-20-2

Ibikoresho bifatika:Liraglutide (igereranya na glucagon ya muntu isa na peptide-1 (GLP-1) ikorwa n'umusemburo binyuze mu ikoranabuhanga rya genoside).

Izina ryimiti:Arg34Lys26- (N-ε- (γ-Glu (N-α-hexadecanoyl))) - GLP-1 [7-37]

Ibindi bikoresho:Disodium Hydrogen Fosifate Dihydrate, Propylene Glycol, Acide Hydrochloric na / cyangwa Sodium Hydroxide (nka pH Adjusters gusa), Fenol, namazi yo gutera inshinge.

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Leuprorelin Acetate igenga ibanga rya hormone ya Gonadal

Izina: Leuprorelin

Numero ya CAS: 53714-56-0

Inzira ya molekulari: C59H84N16O12

Uburemere bwa molekuline: 1209.4

EINECS Numero: 633-395-9

Guhinduranya byihariye: D25 -31.7 ° (c = 1 muri acide acetike 1%)

Ubucucike: 1.44 ± 0.1 g / cm3 (Biteganijwe)

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Boc-We (Trt) -Aib-Gln (Trt) -Gly-OH

Boc-We (Trt) -Aib-Gln (Trt) -Gly-OHni tetrapeptide ikingiwe ikoreshwa muri peptide synthesis hamwe nubushakashatsi bwubatswe. Itsinda rya Boc (tert-butyloxycarbonyl) ririnda N-terminus, mugihe amatsinda ya Trt (trityl) arinda iminyururu yuruhande rwa histidine na glutamine kugirango yirinde kwifata. Kubaho kwa Aib (α-aminoisobutyric aside) biteza imbere guhuza no kongera peptide itajegajega. Iyi peptide ifite agaciro mugukora iperereza rya peptide, itajegajega, kandi nkigishishwa cyo gukora peptide ikora mubuzima.

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BPC-157

BPC-157 API ifata inzira ikomeye ya synthesis (SPPS):
Isuku ryinshi: ≥99% (HPLC detection)
Ibisigisigi bike byanduye, nta endotoxine, nta mwanda uremereye
Gufata neza, gusubiramo cyane, gushyigikira urwego rwo gukoresha
Shigikira garama na kilo urwego rwo gutanga kugirango uhuze ibikenewe mubyiciro bitandukanye kuva R&D kugeza inganda.

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