Pulegone

Pulegone API

Pulegone (formulaire ya molekuline: C₁₀H₁₆O) ni monoterpene ketone ikomoka ku mavuta y’ibimera bisanzwe, iboneka cyane muri mint (Mentha), verbena (Verbena) n’ibimera bifitanye isano. Nkibintu bisanzwe bifite impumuro nziza nibikorwa biologiya, Pulegone yitabiriwe cyane mubijyanye n’imiti karemano, imiti yica udukoko twangiza ibihingwa, imiti ikora buri munsi n’ibikoresho bya farumasi mu myaka yashize.

Pulegone API dutanga ni isuku-yuzuye iboneka binyuze muburyo bwiza bwo gutandukana no kwezwa, byujuje ubuziranenge bwibiciro bya farumasi cyangwa inganda kandi bikwiriye gukoreshwa muburyo butandukanye nkubushakashatsi bwa siyanse niterambere hamwe na synthesis hagati.

Amateka yubushakashatsi ningaruka za farumasi

1. Ingaruka zo kurwanya inflammatory

Umubare munini w’ubushakashatsi bw’inyamaswa n’utugingo ngengabuzima twerekanye ko Pulegone ishobora kubuza irekurwa ry’ibintu bitera indwara (nka TNF-α, IL-1β na IL-6), bikagenga inzira zerekana ibimenyetso bya COX-2 na NF-κB, bityo bikerekana imbaraga zikomeye zo kurwanya indwara ziterwa na rubagimpande nka rubagimpande na rubagimpande.
2. Ingaruka zo gusesengura no gutuza

Pulegone igira ingaruka zimwe na zimwe zo kubuza sisitemu yo hagati kandi ikerekana ingaruka zidasanzwe zo kwerekana imiterere yinyamaswa. Uburyo bwayo bushobora kuba bujyanye no kugenzura sisitemu ya GABA neurotransmitter. Ifite ubushobozi bwo gukoreshwa nkumuti wongeyeho kubibazo byoroheje cyangwa ububabare bwa neuropathique.
3. Ibikorwa bya antibacterial na antifungal

Pulegone igira ingaruka mbi kuri bagiteri zitandukanye za Gram-nziza na Gram-mbi, nka Staphylococcus aureus, Escherichia coli, Bacillus subtilis, nibindi.; irerekana kandi ubushobozi bwo kubuza ibihumyo nka Candida albicans na Aspergillus, kandi ikwiranye no guteza imbere ibidukikije ndetse n’ibicuruzwa bishingiye ku bimera birwanya kwandura.
4. Imikorere yica udukoko nudukoko twica udukoko

Bitewe n'ingaruka zayo zo kubuza sisitemu y'udukoko twangiza udukoko, Pulegone ikoreshwa cyane mu kurwanya udukoko twangiza udukoko twangiza udukoko, ishobora kwirukana imibu, mite, isazi yimbuto, nibindi, kandi ifite ibidukikije bihuza neza nibinyabuzima.
5. Igikorwa gishobora kurwanya ibibyimba (ubushakashatsi bwibanze)

Ubushakashatsi bwibanze bwerekanye ko Pulegone ishobora kugira ingaruka mbi ku ngirabuzimafatizo zimwe na zimwe (nka kanseri y'ibere) itera apoptose, igenga imihangayiko ya okiside ndetse n'imikorere ya mitochondrial, n'ibindi, bitanga umusingi w'ubushakashatsi ku bintu bisanzwe birwanya kanseri.
Imirima yo gusaba hamwe ningaruka ziteganijwe
●Inganda zimiti

Nka molekile isanzwe yiterambere mugutezimbere ibiyobyabwenge, Pulegone irashobora gukoreshwa nkigihe gito kugirango igire uruhare muguhuza menthol (Menthol), menthone, inyongeramusaruro hamwe nibiyobyabwenge bishobora kurwanya anti-inflammatory na antibacterial. Ifite ibyifuzo byinshi muguhindura imiti gakondo yubushinwa no gutegura imiti karemano.
●Amavuta yo kwisiga hamwe nimiti ya buri munsi

Hamwe na aromaticity hamwe nibikorwa bya antibacterial, Pulegone ikoreshwa mugutegura kwoza umunwa karemano, koza umunwa, gukaraba antiseptike, imiti ya mite, imiti yica imibu, nibindi, kugirango ishobore gukenera isoko ryimiti yicyatsi kibisi, irakara cyane, numutekano muke wa buri munsi.
●Ubuhinzi n’ibidukikije byangiza udukoko

Pulegone, nk'ibigize imiti yica udukoko, ikoreshwa mu guteza imbere imiti yica udukoko dushingiye ku bimera ikenerwa mu buhinzi-mwimerere, kugabanya umwanda w’ibidukikije, kuzamura ubwiza bw’ibihingwa, no kubahiriza ingamba zirambye z’iterambere ry’ubuhinzi.
Itsinda rya Gentolex ryiyemeje ubuziranenge

Pulegone API itangwa nitsinda ryacu rya Gentolex ifite ibyiringiro byiza bikurikira:

Isuku ryinshi: ubuziranenge ≥99%, bukwiranye n’imiti n’inganda zo mu rwego rwo hejuru

Yubahiriza ibisabwa na GMP na ISO sisitemu yo gucunga neza ibisabwa

Tanga raporo yubugenzuzi bwuzuye (COA, harimo isesengura rya GC / HPLC, ibyuma biremereye, ibishishwa bisigaye, imipaka ya mikorobe)

Ibisobanuro byihariye birashobora gutangwa ukurikije ibyo abakiriya bakeneye, bishyigikira gutanga kuva kuri garama kugeza ku kilo