Ganirelix Acetate Peptide API

Ibisobanuro bigufi:

Izina: Acetate ya Ganirelix

Numero ya CAS: 123246-29-7

Inzira ya molekulari: C80H113ClN18O13

Uburemere bwa molekuline: 1570.34

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Izina	Ganirelix Acetate
Numero ya CAS	123246-29-7
Inzira ya molekulari	C80H113ClN18O13
Uburemere bwa molekile	1570.34

Synonyme

Ac-DNal-DCpa-DPal-Ser-Tyr-DHar (Et2) -Leu-Har (Et2) -Pro-DAla -NH2; Ganirelixum; ganirelix Acetate;GANIRELIX;Ganirelix Acetate USP / EP /

Ibisobanuro

Ganirelix ni intungamubiri ya decapeptide, hamwe n'umunyu wa acetate, Ganirelix acetate ni imisemburo ya gonadotropine irekura (GnRH) reseptor antagonist.Urukurikirane rwa aside amine ni: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg (9,10-Et2) -Leu-L-HomoArg (9,10-Et2) -Pro- D- Ala-NH2.Ahanini mubuvuzi, ikoreshwa mubagore barimo gukoreshwa muburyo bwimyororokere ifasha kugenzura intanga ngore kugirango birinde imisemburo ya luteinizing imburagihe no kuvura indwara zuburumbuke kubera iyi mpamvu.Uyu muti ufite ibiranga ingaruka nke, umuvuduko mwinshi wo gutwita hamwe nigihe gito cyo kuvura, kandi ufite ibyiza bigaragara ugereranije nibiyobyabwenge bisa mubikorwa byubuvuzi.

Igikorwa cya farumasi

Kurekura kwa pulsatile ya hormone irekura gonadotropine (GnRH) itera synthesis hamwe no gusohora kwa LH na FSH.Inshuro ya LH pulses hagati na nyuma yicyiciro cya 1 ni isaha.Iyi pulses igaragarira mukuzamuka byigihe gito muri serumu LH.Mugihe cyimihango hagati, irekurwa ryinshi rya GnRH ritera kwiyongera kwa LH.Indwara ya LH yo hagati irashobora gukurura ibisubizo byinshi byumubiri, harimo: ovulation, oocyte meiotic resumption, hamwe na corpus luteum.Imiterere ya corpus luteum itera serumu progesterone kuzamuka, mugihe estradiol igabanuka.Ganirelix acetate ni antagonist ya GnRH ihagarika irushanwa ryakira reseptor ya GnRH kuri pitoito gonadotrophs n'inzira za transduction.Itanga umusaruro wihuse, uhindagurika kubuza gonadotropine.Ingaruka zo kubuza ganirelix acetate kumitsi ya LH yari ikomeye kuruta iyo kuri FSH.Ganirelix acetate yananiwe gutera irekurwa rya mbere rya endogenous gonadotropine, ijyanye na antagonism.Kugarura byuzuye kurwego rwa pituito LH na FSH byabaye mugihe cyamasaha 48 nyuma ya ganirelix acetate ihagaritswe.

Mbere: Cetrorelix Acetate kugirango irinde intanga ngore 120287-85-6

Ibikurikira: Linaclotide yo Kurwara Gastrointestinal 851199-59-2

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