Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU ni molekile ya sintetike ya lipide ihuza molekile yagenewe gutanga ibiyobyabwenge hamwe na antibody - ibiyobyabwenge (ADCs). Irimo stearoyl (Ste) hydrophobic umurizo, gl-glutamyl igamije motif, icyogajuru cya AEEA kugirango gihindurwe, hamwe nitsinda rya OSu (NHS ester) kugirango rihuze neza.

 
Ubushakashatsi & Porogaramu:

Byakoreshejwe muburyo bwa prodrug synthesis hamwe na nanocarrier igishushanyo

Gutezimbere imikoranire ya selile no gufata ibiyobyabwenge

Korohereza urubuga rwihariye rwo kwishyiriraho peptide, antibodies, cyangwa abatwara

Ibiranga ibicuruzwa (Itsinda rya Gentolex):

Isuku ryinshi, yiteguye-guhuza NHS ester

Bikwiranye na bioconjugation hamwe nubushakashatsi bugamije gutanga

Ste-γ-Glu-AEEA-AEEA-OSU nibyiza mugutezimbere sisitemu yo gutanga imiti neza.