Atosiban Acetate Yifashishijwe Kurwanya Kubyara
Ibicuruzwa birambuye
| Izina | Atosiban |
| Numero ya CAS | 90779-69-4 |
| Inzira ya molekulari | C43H67N11O12S2 |
| Uburemere bwa molekile | 994.19 |
| Umubare wa EINECS | 806-815-5 |
| Ingingo yo guteka | 1469.0 ± 65.0 ° C (Biteganijwe) |
| Ubucucike | 1.254 ± 0.06 g / cm3 (Biteganijwe) |
| Imiterere yo kubika | -20 ° C. |
| Gukemura | H2O: ≤100 mg / mL |
Ibisobanuro
Atosiban acetate ni disulfide ihujwe na cyclic polypeptide igizwe na acide 9 amine. Ni molekile ya oxytocine yahinduwe kumwanya wa 1, 2, 4 na 8. N-terminus ya peptide ni acide 3-mercaptopropionic aside (thiol na sulfhydryl groupe ya [Cys] 6 ikora umurunga wa disulfide), C-terminal iri muburyo bwa amide, aside amine ya kabiri kuri N-terminal ni Ethylate yahinduwe (D-Tyr) vinegere ibaho muburyo bwumunyu wa aside, bakunze kwita acosate ya atosiban.
Gusaba
Atosiban ni oxytocine na vasopressine V1A ihuriweho na reseptor antagonist, reseptor ya oxytocine isa muburyo bwa vasopressine V1A. Iyo reseptor ya oxytocine ihagaritswe, oxytocine irashobora gukora binyuze muri reseptor ya V1A, bityo rero birakenewe ko uhagarika inzira ebyiri zakira hejuru icyarimwe, kandi antagonism imwe ya reseptor imwe irashobora kubuza neza kugabanuka kwa nyababyeyi. Iyi nayo ni imwe mu mpamvu zingenzi zituma β-reseptor agonist, umuyoboro wa calcium ya calcium na prostaglandine synthase inhibitor idashobora kubuza neza kwikuramo nyababyeyi.
Ingaruka
Atosiban ni reseptor antagonist ya oxytocine na vasopressine V1A, imiterere yimiti isa na byombi, kandi ifite aho ihurira cyane niyakira, kandi irushanwa na oxytocine na vasopressine V1A, bityo bikabuza inzira yibikorwa bya oxytocine na vasopressine no kugabanya ububabare bwa nyababyeyi.
