Ganirelix Acetate Peptide API
Ibicuruzwa birambuye
| Izina | Ganirelix Acetate |
| Numero ya CAS | 123246-29-7 |
| Inzira ya molekulari | C80H113ClN18O13 |
| Uburemere bwa molekile | 1570.34 |
Synonyme
Ac-DNal-DCpa-DPal-Ser-Tyr-DHar (Et2) -Leu-Har (Et2) -Pro-DAla -NH2; Ganirelixum; Acire ya ganirelix; GANIRELIX; Ganirelix Acetate USP / EP /
Ibisobanuro
Ganirelix ni intungamubiri ya decapeptide, hamwe n'umunyu wa acetate, Ganirelix acetate ni imisemburo ya gonadotropine irekura (GnRH) reseptor antagonist. Urutonde rwa aside amine ni: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg (9,10-Et2) -Leu-L-HomoArg (9,10-Et2) -Pro-D- Ala-NH2. Ahanini mubuvuzi, ikoreshwa mubagore barimo gukorerwa tekinoroji yimyororokere igenzurwa na gahunda yo gukurura intanga ngore kugirango birinde imisemburo ya luteinizing imburagihe no kuvura indwara zuburumbuke kubera iyi mpamvu. Uyu muti ufite ibiranga ingaruka nke, umuvuduko mwinshi wo gutwita ndetse nigihe gito cyo kuvura, kandi ufite ibyiza bigaragara ugereranije nibiyobyabwenge bisa mubikorwa byubuvuzi.
Igikorwa cya farumasi
Isohora rya pulsatile ya hormone irekura gonadotropine (GnRH) itera guhuza no gusohora kwa LH na FSH. Inshuro ya LH impiswi hagati na nyuma yicyiciro cya follicular ni hafi 1 kumasaha. Iyi pulses igaragarira mukuzamuka byigihe gito muri serumu LH. Mugihe cyimihango hagati, irekurwa ryinshi rya GnRH ritera kwiyongera kwa LH. Indwara ya LH yo hagati irashobora gukurura ibisubizo byinshi byumubiri, harimo: ovulation, oocyte meiotic resumption, hamwe na corpus luteum. Imiterere ya corpus luteum itera serumu progesterone kwiyongera, mugihe estradiol igabanuka. Ganirelix acetate ni antagonist ya GnRH ibuza guhatanira kwakira reseptor ya GnRH kuri pitoito gonadotrophs n'inzira za transduction. Bitanga byihuse, bidasubirwaho kubuza gonadotropine gusohora. Ingaruka yo kubuza ganirelix acetate kumyunyu ngugu ya LH yari ikomeye kuruta iyo kuri FSH. Ganirelix acetate yananiwe gutera irekurwa ryambere rya endogenous gonadotropine, ijyanye na antagonism. Kugarura byuzuye kurwego rwa pituito LH na FSH byabaye mugihe cyamasaha 48 nyuma ya ganirelix acetate ihagaritswe.
