Carbetocine kugirango wirinde kwandura kwa nyababyeyi no kuva amaraso nyuma yo kubyara
Ibicuruzwa birambuye
| Izina | CARBETOCIN |
| Numero ya CAS | 37025-55-1 |
| Inzira ya molekulari | C45H69N11O12S |
| Uburemere bwa molekile | 988.17 |
| Umubare wa EINECS | 253-312-6 |
| Kuzenguruka byihariye | D -69.0 ° (c = 0,25 muri 1M acide acetike) |
| Ingingo yo guteka | 1477.9 ± 65.0 ° C (Biteganijwe) |
| Ubucucike | 1.218 ± 0.06 g / cm3 (Biteganijwe) |
| Imiterere yo kubika | -15 ° C. |
| Ifishi | ifu |
Synonyme
BUTYRYL-TYR (NJYE) -ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR (NJYE) -ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR (NJYE) 2) -1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR (NJYE) 2) -OXYTOCIN; (BUTYRYL1, TYR (NJYE) 2) -OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE) -DE-AMINO-1-CARBAOXYTOCIN
Igikorwa cyibinyabuzima
Carbetocine, ikigereranyo cya oxytocine (OT), ni oxytocine reseptor agonist hamwe na Ki ya 7.1 nM. Carbetocine ifitanye isano ryinshi (Ki = 1,17 μM) kuri chimeric N-terminus ya reseptor ya oxytocine. Carbetocine ifite ubushobozi bwo gukora ubushakashatsi bwo kuva amaraso nyuma yo kubyara. Carbetocine irashobora kwinjira mu nzitizi yubwonko bwamaraso kandi ikagira ibikorwa bisa na antidepressant mugukoresha reseptor ya oxytocine muri CNS.
Imikorere
Carbetocine ni sintetike ikora ya oxytocine 8-peptide igereranya nibintu bya agonist, kandi imiterere yubuvuzi na farumasi bisa nibya oxytocine isanzwe ibaho. Kimwe na oxytocine, karbetocine ihuza imisemburo ya hormone yakira imitsi yoroshye ya nyababyeyi, igatera injyana ya nyababyeyi, ikongera inshuro zayo kandi ikongera ijwi rya nyababyeyi hashingiwe ku kugabanuka kwumwimerere. Urwego rwa Oxytocine rwakira muri nyababyeyi ruri hasi muri leta idatwite, kwiyongera mugihe utwite, no hejuru cyane mugihe cyo gukora. Kubwibyo, karbetocine nta ngaruka igira kuri nyababyeyi idatwite, ariko igira ingaruka zikomeye zo kwandura kwa nyababyeyi yibungenze ndetse na nyababyeyi nshya.
Hindura Igenzura
Impinduka zigenzurwa ukurikije inzira. Ukurikije ingaruka n'ingaruka n'uburemere, impinduka zashyizwe mubikorwa nka Major, Ntoya na Urubuga. Guhindura urubuga bigira ingaruka nke kumutekano nubuziranenge bwibicuruzwa, bityo ntibikeneye kwemezwa no kubimenyeshwa kubakiriya; Impinduka nto zigira ingaruka zingana kumutekano nubwiza bwibicuruzwa, kandi bigomba kumenyesha umukiriya; Impinduka nini zigira ingaruka nyinshi kumutekano nubwiza bwibicuruzwa, kandi bikeneye kwemezwa nabakiriya.
Ukurikije uburyo, kugenzura kugenzura bitangirana nimpinduka zikoreshwa aho impinduka zirambuye hamwe nimpamvu zifatika zasobanuwe. Isuzuma noneho rikorwa nyuma yo gusaba, bikorwa no kugenzura impinduka ishami rishinzwe. Hagati aho, kugenzura impinduka zashyizwe mubyiciro Bikuru, Urwego Rusange na Ntoya. Nyuma yisuzuma rikwiye kimwe no gutondekanya, kugenzura urwego rwose rugomba kwemezwa na QA Manager. Igenzura rihinduka rikorwa nyuma yo kwemezwa ukurikije gahunda y'ibikorwa. Igenzura rihinduka ryarangije gufungwa nyuma QA yemeje ko kugenzura impinduka zashyizwe mubikorwa neza. Niba harimo kumenyesha abakiriya, umukiriya agomba kubimenyeshwa mugihe nyuma yo kugenzura impinduka zemejwe
