Terlipressine Acetate ya Esophageal Variceal Amaraso
Ibicuruzwa birambuye
| Izina | N- (N- (N-Glycylglycyl) glycyl) -8-L-lysinevasopressin |
| Numero ya CAS | 14636-12-5 |
| Inzira ya molekulari | C52H74N16O15S2 |
| Uburemere bwa molekile | 1227.37 |
| Umubare wa EINECS | 238-680-8 |
| Ingingo yo guteka | 1824.0 ± 65.0 ° C (Biteganijwe) |
| Ubucucike | 1.46 ± 0.1 g / cm3 (Biteganijwe) |
| Imiterere yo kubika | Gumana ahantu hijimye, Inert ikirere, Ubike muri firigo, munsi ya -15 ° C. |
| Coefficient ya acide | (pKa) 9.90 ± 0.15 (Biteganijwe) |
Synonyme
[N-α-Triglycyl-8-lysine] -vasopressine; 130: PN: WO2010033207SEQID: 171claiMedprotein; 1-Triglycyl-8-lysineVasopressine; Nα-Glycyl-glycyl-glycyl- [8-lysine] -vasopressine; Nα-Glycyl-glycyl-glycyl-lysine-vasopressine; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressine; Terlipressine, Terlipressine, Terlipressina, Terlipressinum.
Ibisobanuro
Terlipressine, izina ryayo ryimiti ni triglycyllysine vasopressine, nuburyo bushya bwogukora vasopressine. Nubwoko bwa prodrug, idakora yonyine. Ikorwa na aminopeptidase muri vivo kugirango "irekure" buhoro buhoro lysine vasopressine ikora nyuma yo gukuraho ibisigazwa bitatu bya glycyl kuri N-terminus. Kubwibyo, terlipressine ikora nk'ikigega gisohora lysine vasopressine ku gipimo gihamye.
Ingaruka ya farumasi ya terlipressine ni ukwandura imitsi ya splanchnic vascular yoroshye imitsi no kugabanya umuvuduko wamaraso wa splanchnic (nko kugabanya umuvuduko wamaraso muri mesentery, spleen, nyababyeyi, nibindi), bityo bikagabanya umuvuduko wamaraso hamwe numuvuduko wurubuga. Ku rundi ruhande, irashobora kandi kugabanya plasma Ingaruka ziterwa na renin, bityo bikongera umuvuduko wamaraso wimpyiko, kunoza imikorere yimpyiko no kongera inkari mubarwayi barwaye syndrome de hepatorenal. Muri iki gihe Terlipressine niwo muti wonyine ushobora kuzamura imibereho y’abarwayi bafite amaraso ava mu mitsi. Byakoreshejwe cyane cyane mubuvuzi bwo kuvura amaraso. Byongeye kandi, terlipressine nayo yakoreshejwe neza mu mwijima no mu mpyiko. Muri rusange, birashoboka ko byagira uruhare runini mukubana guhungabana hamwe no kuvura indwara z'umutima. Ugereranije na vasopressine, igira ingaruka zirambye, ntizitera ingorane ziteye akaga, harimo fibrinolysis hamwe ningorane zikomeye muri sisitemu yumutima nimiyoboro yimitsi, kandi biroroshye gukoresha (inshinge zinjira mumitsi), zikwiranye nubuvuzi bukomeye kandi bukomeye. Gutabara no kuvura abarwayi barembye cyane.
