Terlipressin acetate kumava ya esophageal elekice
Ibisobanuro birambuye
| Izina | N- (n- (n-glycylglyycyl) glycyl) -8-L-LysinevaSopressin |
| Umubare wa Cas | 14636-12-5 |
| Formulala | C52H74N16O15S2 |
| Uburemere bwa molekile | 1227.37 |
| Umubare wa EINECS | 238-680-8 |
| Ingingo itetse | 1824.0 ± 65.0 ° C (Byahanuwe) |
| Ubucucike | 1.46 ± 0.1 g / cm3 (byahanuwe) |
| Imiterere | Komeza ahantu hijimye, ikirere cya inert, ububiko muri firigo, munsi ya -15 ° C. |
| Coeffity | (PKA) 9.90 ± 0.15 (byahanuwe) |
Synonyme
[N-triglycyl-8-Lysine] -Visopressin; 130: pn: wo2010033207Seqid; 1-Triglyyl-8-LysinevaSopressin; Nα-glycyl-glycyl-glycyl- [8-Lysine] -vasipressin; Nα-glycyl-glycyl-glycyl-lysine-vasopressin; Nα-glycylglycylylglyycyl-Vasopressin; Nα-gly-gly-gly-8-8-lys-vasopressin; Terlipressin, Terlipressine, Terlipressina, Terlipressinum.
Ibisobanuro
Terlipressin, ni izina rya shimi rya triglycyllysine vasopressin, ni usvertheque nshya yo gutegura vasopressin. Nubwoko bwa prodrug, idakora ubwayo. Byakozwe na Aminopptidase muri Vivo kugeza buhoro "kurekura" Lysine Vesopressin nyuma yo gukuraho ibisiga bitatu bya Glycyl kuri n-termis. Kubwibyo, ibikorwa bya terliprestin nkigishyimbo cyerekana Lysine Vasopressin ku gipimo gihamye.
Ingaruka ya farumasi ya Terlipressin nuguhindura imitsi yoroshye kandi igabanya amaraso ya splanch (nko kugabanya amaraso muri meser, mu buryo bugabana Ku rundi ruhande, irashobora kandi kugabanya plasma ingaruka zo kwibanda kuri Renin, bityo biyongera amaraso yamenetse, atezimbere imikorere yimpyiko, yongerera imikorere yimpyiko kandi yongera ibisohoka mu barwayi syndrome ya Hepatorenal. Kuri ubu terlipressin kuri ubu ni ibiyobyabwenge byonyine bishobora kunoza igipimo cyo kubaho kubarwayi hamwe na valicel varicel varicel varicel. Byakoreshejwe cyane mu kuvura ivuriro rya Herlande. Byongeye kandi, terlipressin nayo yakoreshejwe neza mu mwijima n'impyiko. Muri rusange, birashoboka ko tuzagira uruhare rufite akamaro mubana ihungabana ryoroshye hamwe no kuzungura umutima. Ugereranije na Vasopressin, bifite ingaruka ndende, ntabwo itera ibibazo biteje akaga, harimo na fibrinolysis hamwe nibibazo bikomeye muri sisitemu yumutima, kandi biroroshye gukoresha (gukomera) Gutabara no kuvura abarwayi barwaye cyane.
