Linaclotide yo Kurwara Gastrointestinal 851199-59-2
Ibicuruzwa birambuye
| Izina | Linaclotide |
| Numero ya CAS | 851199-59-2 |
| Inzira ya molekulari | C59H79N15O21S6 |
| Uburemere bwa molekile | 1526.74 |
Synonyme
Linacllotide; Linaclotide; -L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1 → 6), (2 → 10), (5 → 13) -tris (disulfide)
Ibisobanuro
Linaclotide, imiterere ya peptide yubukorikori irimo aside amine 14, ifitanye isano na endogenous guanosine peptide yumuryango kandi niyo miti yonyine yemewe na FDA ya GC-C (guanylate) Cyclase-C) imiti igabanya ubukana bwa syndrome de munda hamwe na constipation (IBS-C) hamwe no kuribwa mu nda idakira (CIC) mubantu bakuru.
Ibikoresho bya Shimi
Linaclotide ni ifu yera-yera-ifu ya amorphous; gushonga gake mumazi hamwe na sodium ya chloride yumuti (0.9%).
Uburyo ikora
Linaclotide ni guanylate cyclase-C reseptor agonist (GCCA) hamwe nibikorwa bya analgesique ya visceral na endocrine. Byombi linaclotide hamwe na metabolite ikora irashobora guhuza na reseptor ya guanylate cyclase-C (GC-C) hejuru yumucyo wa epitelium ntoya. Mubyitegererezo byinyamanswa, linaclotide igabanya ububabare bwimyanya ndangagitsina kandi ikongera gastrointestinal transit binyuze mumikorere ya GC-C, kandi mubantu, ibiyobyabwenge nabyo byongera inzira ya colonike. Igisubizo cyo gukora GC-C cyongerewe imbaraga za cGMP zidasanzwe (selile cyclic guanosine monophosphate). CGMP idasanzwe irashobora kugabanya ibikorwa byububabare bwimyanya myibarukiro no kugabanya ububabare bwimyanya ndangagitsina mu nyamaswa ntangarugero. Indwara ya cGMP irashobora kongera ururenda rwa chloride na bicarbonate mu mara mato ukoresheje CFTR (cystic fibrosis transmembrane conductance regulor), amaherezo iganisha ku kwiyongera kw'amazi mato mato yo mu mara n'umuvuduko wo gutembera mu mara mato.
Ibibazo
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